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Structure of aspartoacylase, the brain enzyme impaired in Canavan disease
Aspartoacylase catalyzes hydrolysis of N-acetyl-l-aspartate to aspartate and acetate in the vertebrate brain. Deficiency in this activity leads to spongiform degeneration of the white matter of the brain and is the established cause of Canavan disease, a fatal progressive leukodystrophy affecting yo...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1766406/ https://ncbi.nlm.nih.gov/pubmed/17194761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607817104 |
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