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Molecular Structure of Amyloid Fibrils Controls the Relationship between Fibrillar Size and Toxicity
BACKGROUND: According to the prevailing view, soluble oligomers or small fibrillar fragments are considered to be the most toxic species in prion diseases. To test this hypothesis, two conformationally different amyloid states were produced from the same highly pure recombinant full-length prion pro...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3098877/ https://ncbi.nlm.nih.gov/pubmed/21625461 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020244 |
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