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The polybasic N-terminal region of the prion protein controls the physical properties of both the cellular and fibrillar forms of PrP
Individual variations in structure and morphology of amyloid fibrils produced from a single polypeptide are likely to underlie the molecular origin of prion strains and control the efficiency of the species barrier in transmission of prions. Previously, we observed that the shape of amyloid fibrils...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597535/ https://ncbi.nlm.nih.gov/pubmed/18789949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.08.073 |
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