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A novel bispecific ligand-directed toxin designed to simultaneously target EGFR on human glioblastoma cells and uPAR on tumor neovasculature

A bispecific ligand-directed toxin (BLT), called EGFATFKDEL, consisting of human epidermal growth factor, a fragment of urokinase, and truncated pseudomonas exotoxin (PE38) was assembled in order to target human glioblastoma. Immunogenicity was reduced by mutating seven immunodominant B-cell epitope...

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Bibliografiske detaljer
Main Authors: Tsai, Alexander K., Oh, Seunguk, Chen, Hua, Shu, Yanqun, Ohlfest, John R., Vallera, Daniel A.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098297/
https://ncbi.nlm.nih.gov/pubmed/20830604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-010-0392-5
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