A meningococcal factor H binding protein mutant that eliminates factor H binding enhances protective antibody responses to vaccination

Certain pathogens recruit host complement inhibitors such as factor H (fH) to evade the immune system. Microbial complement inhibitor-binding molecules can be promising vaccine targets by eliciting antibodies that neutralize this microbial defense mechanism. One such antigen, meningococcal fH-bindin...

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Bibliographic Details
Main Authors: Beernink, Peter T., Shaughnessy, Jutamas, Braga, Emily M., Liu, Qin, Rice, Peter A., Ram, Sanjay, Granoff, Dan M.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098282/
https://ncbi.nlm.nih.gov/pubmed/21325619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003470
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