Inhibition of Both HIV-1 Reverse Transcription and Gene Expression by a Cyclic Peptide that Binds the Tat-Transactivating Response Element (TAR) RNA

The RNA response element TAR plays a critical role in HIV replication by providing a binding site for the recruitment of the viral transactivator protein Tat. Using a structure-guided approach, we have developed a series of conformationally-constrained cyclic peptides that act as structural mimics o...

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Autors principals: Lalonde, Matthew S., Lobritz, Michael A., Ratcliff, Annette, Chamanian, Mastooreh, Athanassiou, Zafiria, Tyagi, Mudit, Wong, Julian, Robinson, John A., Karn, Jonathan, Varani, Gabriele, Arts, Eric J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098202/
https://ncbi.nlm.nih.gov/pubmed/21625572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002038
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