Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis is a relentless and devastating adult-onset neurodegenerative disease with no known cure. In mice with amyotrophic lateral sclerosis, CD4(+) T lymphocytes and wild-type microglia potentiate protective inflammatory responses and play a principal role in disease pathoprog...

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Main Authors: Beers, David R., Henkel, Jenny S., Zhao, Weihua, Wang, Jinghong, Huang, Ailing, Wen, Shixiang, Liao, Bing, Appel, Stanley H.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2011
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3097891/
https://ncbi.nlm.nih.gov/pubmed/21596768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awr074
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