The role of the preserved sequences of Dam methylase.
We have undertaken a site directed mutational analysis of two of the preserved regions in the amino acid sequence of Dam methylase in order to characterize their role. Mutations in region IV (sequence DPPY) abolish catalytic activity and greatly affect AdoMet crosslinking. Mutants in region III disp...
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| Veröffentlicht in: | Nucleic Acids Res |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
1993
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| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC309753/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8341592/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/21.14.3183 |
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