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A Mathematical Model of Human Thymidine Kinase 2 Activity
The mitochondrial enzyme thymidine kinase 2 (TK2) phosphorylates deoxythymidine (dT) and deoxycytidine (dC) to form dTMP and dCMP, which in cells rapidly become the negative-feedback end-products dTTP and dCTP. TK2 kinetic activity exhibits Hill coefficients of ~0.5 (apparent negative cooperativity)...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3097248/ https://ncbi.nlm.nih.gov/pubmed/21491329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15257770.2011.563765 |
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