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Networked Human Telomerase Domain Interactions Capture the Template-paired Substrate and Single-stranded Product for Processive Elongation

Eukaryotic chromosome maintenance requires telomeric repeat synthesis by telomerase. It remains uncertain how telomerase domains interact to organize the active RNP and how this architecture establishes the specificity of the catalytic cycle. We combine human telomerase reconstitutions in vivo, affi...

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Detalhes bibliográficos
Main Authors: Robart, Aaron R., Collins, Kathleen
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3097130/
https://ncbi.nlm.nih.gov/pubmed/21514196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.03.012
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