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Networked Human Telomerase Domain Interactions Capture the Template-paired Substrate and Single-stranded Product for Processive Elongation
Eukaryotic chromosome maintenance requires telomeric repeat synthesis by telomerase. It remains uncertain how telomerase domains interact to organize the active RNP and how this architecture establishes the specificity of the catalytic cycle. We combine human telomerase reconstitutions in vivo, affi...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3097130/ https://ncbi.nlm.nih.gov/pubmed/21514196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.03.012 |
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