17-allyamino-17-demethoxygeldanamycin treatment results in a magnetic resonance spectroscopy-detectable elevation in choline-containing metabolites associated with increased expression of choline transporter SLC44A1 and phospholipase A2

INTRODUCTION: 17-allyamino-17-demethoxygeldanamycin (17-AAG), a small molecule inhibitor of Hsp90, is currently in clinical trials in breast cancer. However, 17-AAG treatment often results in inhibition of tumor growth rather than shrinkage, making detection of response a challenge. Magnetic resonan...

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Bibliographic Details
Main Authors: Brandes, Alissa H, Ward, Christopher S, Ronen, Sabrina M
Format: Artigo
Language:Inglês
Published: BioMed Central 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096977/
https://ncbi.nlm.nih.gov/pubmed/20946630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2729
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