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Measurements of tumor cell autophagy predict invasiveness, resistance to chemotherapy, and survival in melanoma

PURPOSE: Autophagy consists of lysosome-dependent degradation of cytoplasmic contents sequestered by autophagic vesicles (AV). The role of autophagy in determining tumor aggressiveness and response to therapy in melanoma was investigated in this study. EXPERIMENTAL DESIGN: Autophagy was measured in...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ma, Xiaohong, Piao, Shengfu, Wang, Dan, Mcafee, Quentin, Nathanson, Katherine L., Lum, Julian J., Li, Lin Z., Amaravadi, Ravi K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096713/
https://ncbi.nlm.nih.gov/pubmed/21325076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-2372
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