Expression of HLA Class II Molecules in Humanized NOD.Rag1KO.IL2RgcKO Mice Is Critical for Development and Function of Human T and B Cells

BACKGROUND: Humanized mice able to reconstitute a surrogate human immune system (HIS) can be used for studies on human immunology and may provide a predictive preclinical model for human vaccines prior to clinical trials. However, current humanized mouse models show sub-optimal human T cell reconsti...

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Detalhes bibliográficos
Main Authors: Danner, Rebecca, Chaudhari, Snehal N., Rosenberger, John, Surls, Jacqueline, Richie, Thomas L., Brumeanu, Teodor-Doru, Casares, Sofia
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096643/
https://ncbi.nlm.nih.gov/pubmed/21611197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019826
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