Conformational mAb as a Tool for Integrin Ligand Discovery

α(4)β(1)-Integrin (very late antigen-4 (VLA-4)) mediates cell adhesion to cell surface ligands (VCAM-1). Binding of VLA-4 to VCAM-1 initiates rolling and firm adhesion of leukocytes to vascular endothelium followed by the extravasation into the tissue. VLA-4-dependent adhesion plays a key role in co...

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Autores principales: Njus, Ben H., Chigaev, Alexandre, Waller, Anna, Wlodek, Danuta, Ostopovici-Halip, Liliana, Ursu, Oleg, Wang, Wei, Oprea, Tudor I., Bologa, Cristian G., Sklar, Larry A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. publishers 2009
Materias:
Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096548/
https://ncbi.nlm.nih.gov/pubmed/19754304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2009.0203
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