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The glucocorticoid receptor hormone binding domain mediates transcriptional activation in vitro in the absence of ligand.

We show that recombinant rat glucocorticoid receptor (vvGR) expressed using vaccinia virus is indistinguishable from authentic GR with respect to DNA and hormone binding. In the absence of hormone, vvGR is mainly found in the cytoplasm in a complex with heat shock protein 90. Upon incubation with li...

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Detalles Bibliográficos
Main Authors: Schmitt, J, Stunnenberg, H G
Formato: Artigo
Idioma:Inglês
Publicado: 1993
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC309598/
https://ncbi.nlm.nih.gov/pubmed/8392705
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