Simvastatin Attenuates Radiation-Induced Murine Lung Injury and Dysregulated Lung Gene Expression

Novel therapies are desperately needed for radiation-induced lung injury (RILI), which, despite aggressive corticosteroid therapy, remains a potentially fatal and dose-limiting complication of thoracic radiotherapy. We assessed the utility of simvastatin, an anti-inflammatory and lung barrier–protec...

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Main Authors: Mathew, Biji, Huang, Yong, Jacobson, Jeffrey R., Berdyshev, Evegeny, Gerhold, Lynnette M., Wang, Ting, Moreno-Vinasco, Liliana, Lang, Gabriel, Zhao, Yutong, Chen, Chin Tu, LaRiviere, Patrick J., Mauceri, Helena, Sammani, Saad, Husain, Aliya N., Dudek, Steven M., Natarajan, Viswanathan, Lussier, Yves A., Weichselbaum, Ralph R., Garcia, Joe G. N.
Format: Artigo
Jezik:Inglês
Izdano: American Thoracic Society 2011
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3095940/
https://ncbi.nlm.nih.gov/pubmed/20508068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2010-0122OC
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