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Brief Report: The Kras Mutational Spectra of Chemically Induced Lung Tumors in Different Inbred Mice Mimics the Spectra of KRAS Mutations in Adenocarcinomas in Smokers vs Non-smokers

In highly susceptible A/J mice, lung adenomas develop spontaneously and can also be induced by the tobacco carcinogen, 3-methylcholanthrene (MCA). If MCA administration is followed by butylated hydroxytoluene (BHT)-elicited chronic inflammation, tumor multiplicity increases. The distribution of Kras...

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Bibliografiske detaljer
Main Authors: Fritz, Jason M., Dwyer-Nield, Lori D., Russell, Bridgette M., Malkinson, Alvin M.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3095832/
https://ncbi.nlm.nih.gov/pubmed/20101149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0b013e3181c8ce04
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