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Brief Report: The Kras Mutational Spectra of Chemically Induced Lung Tumors in Different Inbred Mice Mimics the Spectra of KRAS Mutations in Adenocarcinomas in Smokers vs Non-smokers
In highly susceptible A/J mice, lung adenomas develop spontaneously and can also be induced by the tobacco carcinogen, 3-methylcholanthrene (MCA). If MCA administration is followed by butylated hydroxytoluene (BHT)-elicited chronic inflammation, tumor multiplicity increases. The distribution of Kras...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3095832/ https://ncbi.nlm.nih.gov/pubmed/20101149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0b013e3181c8ce04 |
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