Frequency and Distinctive Spectrum of KRAS Mutations in Never Smokers with Lung Adenocarcinoma

PURPOSE: KRAS mutations are found in ~ 25% of lung adenocarcinomas in Western countries and, as a group, have been strongly associated with cigarette smoking. These mutations are predictive of poor prognosis in resected disease as well as resistance to treatment with erlotinib or gefitinib. EXPERIME...

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Detalhes bibliográficos
Main Authors: Riely, Gregory J., Kris, Mark G., Rosenbaum, Daniel, Marks, Jenifer, Li, Allan, Chitale, Dhananjay A., Nafa, Khedoudja, Riedel, Elyn R., Hsu, Meier, Pao, William, Miller, Vincent A., Ladanyi, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754127/
https://ncbi.nlm.nih.gov/pubmed/18794081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-0646
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