Anticancer and antiangiogenic activity of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer therapy

Tumor progression is dependent on neoangiogenesis for blood supply. Neovasculature over-express α(v)β(3) integrins which recognize the Arg-Gly-Asp (RGD) sequence in the extracellular matrix. N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers containing side chains terminated in cyclic RGD analogs s...

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Bibliografiset tiedot
Päätekijät: Greish, Khaled, Ray, Abhijit, Bauer, Hillevi, Larson, Nate, Malugin, Alexander, Pike, Daniel, Haider, Mohamed, Ghandehari, Hamidreza
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3095727/
https://ncbi.nlm.nih.gov/pubmed/21223983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2010.12.015
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