KNOCKDOWN OF GCN5 HISTONE ACETYLTRANSFERASE by siRNA DECREASES ETHANOL INDUCED HISTONE ACETYLATION AND AFFECTS DIFFERENTIAL EXPRESSION OF GENES IN HUMAN HEPATOMA CELLS

We have investigated whether Gcn5, a histone acetyltransferase (HAT), is involved in ethanol induced acetylation of histone H3 at lysine 9 (H3AcK9) and has any effect on the gene expression. Human hepatoma HepG2 cells transfected with ethanol metabolizing enzyme alcohol dehydrogenase 1 (VA 13 cells)...

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Bibliografiske detaljer
Main Authors: Choudhury, Mahua, Pandey, Ravi S., Clemens, Dahn L., Davis, J. Wade, Lim, Robert W., Shukla, Shivendra D.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3095692/
https://ncbi.nlm.nih.gov/pubmed/21367571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.alcohol.2010.12.003
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