Hyperactivation of NF-κB via the MEK signaling is indispensable for the inhibitory effect of cAMP on DNA damage-induced cell death

With cAMP signaling having a profound inhibitory effect on DNA damage-induced apoptosis in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells, understanding how this signaling pathway affects the survival capacity of the cell has important implications for cancer therapy. We have recently...

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Main Authors: Kloster, Martine M, Naderi, Elin H, Carlsen, Harald, Blomhoff, Heidi K, Naderi, Soheil
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3095569/
https://ncbi.nlm.nih.gov/pubmed/21510868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-45
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