Influence of Host Gene Transcription Level and Orientation on HIV-1 Latency in a Primary-Cell Model

Human immunodeficiency virus type 1 (HIV-1) establishes a latent reservoir in resting memory CD4(+) T cells. This latent reservoir is a major barrier to the eradication of HIV-1 in infected individuals and is not affected by highly active antiretroviral therapy (HAART). Reactivation of latent HIV-1...

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Autori principali: Shan, Liang, Yang, Hung-Chih, Rabi, S. Alireza, Bravo, Hector C., Shroff, Neeta S., Irizarry, Rafael A., Zhang, Hao, Margolick, Joseph B., Siliciano, Janet D., Siliciano, Robert F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2011
Soggetti:
Genome Replication and Regulation of Viral Gene Expression
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094997/
https://ncbi.nlm.nih.gov/pubmed/21430059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02536-10
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