Pseudotyping Vesicular Stomatitis Virus with Lymphocytic Choriomeningitis Virus Glycoproteins Enhances Infectivity for Glioma Cells and Minimizes Neurotropism

Vesicular stomatitis virus (VSV)-based oncolytic virotherapy has the potential to significantly improve the prognosis of aggressive malignancies such as brain cancer. However, VSV's inherent neurotoxicity has hindered clinical development so far. Given that this neurotropism is attributed to th...

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Détails bibliographiques
Auteurs principaux: Muik, Alexander, Kneiske, Inna, Werbizki, Marina, Wilflingseder, Doris, Giroglou, Tsanan, Ebert, Oliver, Kraft, Anna, Dietrich, Ursula, Zimmer, Gert, Momma, Stefan, von Laer, Dorothee
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2011
Sujets:
Pathogenesis and Immunity
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094995/
https://ncbi.nlm.nih.gov/pubmed/21450833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02511-10
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