Pseudotyping Vesicular Stomatitis Virus with Lymphocytic Choriomeningitis Virus Glycoproteins Enhances Infectivity for Glioma Cells and Minimizes Neurotropism

Vesicular stomatitis virus (VSV)-based oncolytic virotherapy has the potential to significantly improve the prognosis of aggressive malignancies such as brain cancer. However, VSV's inherent neurotoxicity has hindered clinical development so far. Given that this neurotropism is attributed to th...

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Main Authors: Muik, Alexander, Kneiske, Inna, Werbizki, Marina, Wilflingseder, Doris, Giroglou, Tsanan, Ebert, Oliver, Kraft, Anna, Dietrich, Ursula, Zimmer, Gert, Momma, Stefan, von Laer, Dorothee
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2011
Teme:
Pathogenesis and Immunity
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094995/
https://ncbi.nlm.nih.gov/pubmed/21450833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02511-10
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