Pseudotyping Vesicular Stomatitis Virus with Lymphocytic Choriomeningitis Virus Glycoproteins Enhances Infectivity for Glioma Cells and Minimizes Neurotropism

Vesicular stomatitis virus (VSV)-based oncolytic virotherapy has the potential to significantly improve the prognosis of aggressive malignancies such as brain cancer. However, VSV's inherent neurotoxicity has hindered clinical development so far. Given that this neurotropism is attributed to th...

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Bibliographische Detailangaben
Hauptverfasser: Muik, Alexander, Kneiske, Inna, Werbizki, Marina, Wilflingseder, Doris, Giroglou, Tsanan, Ebert, Oliver, Kraft, Anna, Dietrich, Ursula, Zimmer, Gert, Momma, Stefan, von Laer, Dorothee
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2011
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094995/
https://ncbi.nlm.nih.gov/pubmed/21450833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02511-10
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