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Phenotypic Suppression of a Herpes Simplex Virus 1 ICP27 Mutation by Enhanced Transcription of the Mutant Gene
ICP27 is an essential herpes simplex virus 1 (HSV-1) regulatory protein that enhances viral gene expression. Although it is predominantly nuclear, it shuttles to the cytoplasm during infection using an N-terminal nuclear export signal (NES). We previously engineered an NES-negative ICP27 mutant, dLe...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3094987/ https://ncbi.nlm.nih.gov/pubmed/21411532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00315-11 |
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