An Early HIV Mutation within an HLA-B*57-Restricted T Cell Epitope Abrogates Binding to the Killer Inhibitory Receptor 3DL1

Mutations within MHC class I-restricted epitopes have been studied in relation to T cell-mediated immune escape, but their impact on NK cells via interaction with killer Ig-like receptors (KIRs) during early HIV infection is poorly understood. In two patients acutely infected with HIV-1, we observed...

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Main Authors: Brackenridge, Simon, Evans, Edward J., Toebes, Mireille, Goonetilleke, Nilu, Liu, Michael K. P., di Gleria, Kati, Schumacher, Ton N., Davis, Simon J., McMichael, Andrew J., Gillespie, Geraldine M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094954/
https://ncbi.nlm.nih.gov/pubmed/21430058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00238-11
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