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Identification of a Single Amino Acid Required for APOBEC3 Antiretroviral Cytidine Deaminase Activity
During studies of APOBEC3 (A3) anti-human immunodeficiency virus type 1 (anti-HIV-1) mechanisms, we identified a single cysteine at position 320 (C320) that disrupts A3DE activity. This residue is located in the recently identified DNA binding domain in A3G. Replacing C320 with a corresponding tyros...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3094948/ https://ncbi.nlm.nih.gov/pubmed/21430060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00243-11 |
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