Mutagenic Tests Confirm That New Acetylacetonate Pt(II) Complexes Induce Apoptosis in Cancer Cells Interacting with Nongenomic Biological Targets

New platinum(II) complexes [PtCl(O,O′-acac)(L)] (1) and [Pt(O,O′-acac)(γ-acac)(L)] (2) (L = DMSO, a; DMS, b) containing a single chelated (O,O′-acac) (1), or one chelated and one σ-bonded (γ-acac) acetylacetonate (2) have been synthesized. The new Pt(II) complexes exhibited high in vitro cytotoxicit...

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Detalhes bibliográficos
Main Authors: De Pascali, Sandra Angelica, Lugoli, Federica, De Donno, Antonella, Fanizzi, Francesco Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094815/
https://ncbi.nlm.nih.gov/pubmed/21792272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/763436
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