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Asymmetric Synthesis of α-Keto Esters via Cu(II)-Catalyzed Aerobic Deacylation of Acetoacetate Alkylation Products: An Unusually Simple Synthetic Equivalent to the Glyoxylate Anion Synthon

[Image: see text] A simple and efficient method for the preparation of β-stereogenic α-keto esters is described using a copper(II)-catalyzed aerobic deacylation of substituted acetoacetate esters. The substrates for the title process arise from catalytic, enantioselective conjugate additions and alk...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Steward, Kimberly M., Johnson, Jeffrey S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094151/
https://ncbi.nlm.nih.gov/pubmed/21486076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol200649u
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