Histone H3K4 trimethylation by MLL3 as part of ASCOM complex is critical for NR activation of bile acid transporter genes and is downregulated in cholestasis

The nuclear receptor Farnesoid x receptor (FXR) is a critical regulator of multiple genes involved in bile acid homeostasis. The coactivators attracted to promoters of FXR target genes and epigenetic modifications that occur after ligand binding to FXR have not been completely defined, and it is unk...

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Hlavní autoři: Ananthanarayanan, M., Li, Yanfeng, Surapureddi, S., Balasubramaniyan, N., Ahn, Jaeyong, Goldstein, J. A., Suchy, Frederick J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2011
Témata:
Liver and Biliary Tract
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094144/
https://ncbi.nlm.nih.gov/pubmed/21330447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00499.2010
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