Histone H3K4 trimethylation by MLL3 as part of ASCOM complex is critical for NR activation of bile acid transporter genes and is downregulated in cholestasis

The nuclear receptor Farnesoid x receptor (FXR) is a critical regulator of multiple genes involved in bile acid homeostasis. The coactivators attracted to promoters of FXR target genes and epigenetic modifications that occur after ligand binding to FXR have not been completely defined, and it is unk...

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Detalhes bibliográficos
Main Authors: Ananthanarayanan, M., Li, Yanfeng, Surapureddi, S., Balasubramaniyan, N., Ahn, Jaeyong, Goldstein, J. A., Suchy, Frederick J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Liver and Biliary Tract
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094144/
https://ncbi.nlm.nih.gov/pubmed/21330447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00499.2010
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