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CCAAT/enhancer binding protein β-deficiency enhances type 1 diabetic bone phenotype by increasing marrow adiposity and bone resorption

Bone loss in type 1 diabetes is accompanied by increased marrow fat, which could directly reduce osteoblast activity or result from altered bone marrow mesenchymal cell lineage selection (adipocyte vs. osteoblast). CCAAT/enhancer binding protein beta (C/EBPβ) is an important regulator of both adipoc...

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Autors principals: Motyl, Katherine J., Raetz, Michelle, Tekalur, Srinivasan Arjun, Schwartz, Richard C., McCabe, Laura R.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094035/
https://ncbi.nlm.nih.gov/pubmed/21346244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00764.2010
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