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Bisphosphonate treatment of type I diabetic mice prevents early bone loss but accentuates suppression of bone formation

Type I (T1) diabetes is an autoimmune and metabolic disease associated with bone loss. Previous studies demonstrate that T1-diabetes decreases osteoblast activity and viability. Bisphosphonate therapy, commonly used to treat osteoporosis, is demonstrated to inhibit osteoclast activity as well as ost...

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Detalhes bibliográficos
Publicado no:J Cell Physiol
Main Authors: Coe, Lindsay M., Tekalur, Srinivasan Arjun, Shu, Yutian, Baumann, Melissa J., McCabe, Laura R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724196/
https://ncbi.nlm.nih.gov/pubmed/25641511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.24929
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