Cysteine Oxidation within N-terminal Mutant Huntingtin Promotes Oligomerization and Delays Clearance of Soluble Protein

Huntington disease (HD) is a progressive neurodegenerative disorder caused by expression of polyglutamine-expanded mutant huntingtin protein (mhtt). Most evidence indicates that soluble mhtt species, rather than insoluble aggregates, are the important mediators of HD pathogenesis. However, the diffe...

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Detalhes bibliográficos
Main Authors: Fox, Jonathan H., Connor, Teal, Stiles, Megan, Kama, Jibrin, Lu, Zhen, Dorsey, Kathryn, Liebermann, Gregory, Sapp, Ellen, Cherny, Robert A., Banks, Mary, Volitakis, Irene, DiFiglia, Marian, Berezovska, Oksana, Bush, Ashley I., Hersch, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093904/
https://ncbi.nlm.nih.gov/pubmed/21454633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.199448
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