Mechanism of Intracellular cAMP Sensor Epac2 Activation: cAMP-INDUCED CONFORMATIONAL CHANGES IDENTIFIED BY AMIDE HYDROGEN/DEUTERIUM EXCHANGE MASS SPECTROMETRY (DXMS)

Epac2, a guanine nucleotide exchange factor, regulates a wide variety of intracellular processes in response to second messenger cAMP. In this study, we have used peptide amide hydrogen/deuterium exchange mass spectrometry to probe the solution structural and conformational dynamics of full-length E...

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Bibliografiske detaljer
Main Authors: Li, Sheng, Tsalkova, Tamara, White, Mark A., Mei, Fang C., Liu, Tong, Wang, Daphne, Woods, Virgil L., Cheng, Xiaodong
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093864/
https://ncbi.nlm.nih.gov/pubmed/21454623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.224535
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