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The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival

eIF4E is overexpressed in many tumors, including a high proportion of breast cancers. eIF4E is an oncogene, and signaling pathways which promote eIF4E activity represent potential targets for therapeutic intervention in cancer. MNKs phosphorylate eIF4E on serine 209, a modification that can be requi...

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Bibliografski detalji
Glavni autori: Wheater, Matthew J, Johnson, Peter WM, Blaydes, Eremy P
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093812/
https://ncbi.nlm.nih.gov/pubmed/20686366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.10.7.12965
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