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The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival
eIF4E is overexpressed in many tumors, including a high proportion of breast cancers. eIF4E is an oncogene, and signaling pathways which promote eIF4E activity represent potential targets for therapeutic intervention in cancer. MNKs phosphorylate eIF4E on serine 209, a modification that can be requi...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Landes Bioscience
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3093812/ https://ncbi.nlm.nih.gov/pubmed/20686366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.10.7.12965 |
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