ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors

We describe a role for ECM as a biosensor for inflammatory microenvironments that plays a critical role in peripheral immune tolerance. We show that hyaluronan (HA) promotes induction of Foxp3- IL-10–producing regulatory T cells (TR1) from conventional T-cell precursors in both murine and human syst...

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Autors principals: Bollyky, Paul L., Wu, Rebecca P., Falk, Ben A., Lord, James D., Long, S. Alice, Preisinger, Anton, Teng, Brandon, Holt, Gregory E., Standifer, Nathan E., Braun, Kathleen R., Xie, Cindy Fang, Samuels, Peter L., Vernon, Robert B., Gebe, John A., Wight, Thomas N., Nepom, Gerald T.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093524/
https://ncbi.nlm.nih.gov/pubmed/21518860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017360108
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