CD44 co-stimulation promotes FoxP3+ regulatory T-cell persistence and function via production of IL-2, IL-10 and TGF-beta

Work by our group and others has demonstrated a role for the extracellular matrix receptor CD44 and it's ligand hyaluronan in CD4+CD25+ regulatory T-cell (Treg) function. Herein we explore the mechanistic basis for this observation. Using mouse FoxP3/GFP+ Treg we find that CD44 co-stimulation p...

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Detalhes bibliográficos
Main Authors: Bollyky, Paul L., Falk, Ben A., Long, Alice, Preisinger, Anton, Braun, Kathy R., Wu, Rebecca P., Evanko, Stephen P., Buckner, Jane H., Wight, Thomas N., Nepom, Gerald T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057032/
https://ncbi.nlm.nih.gov/pubmed/19635906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0900191
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