Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse

Hyaluronan (HA) production by dendritic cells (DCs) is known to promote antigen presentation and to augment T-cell activation and proliferation. We hypothesized that pericellular HA can function as intercellular ‘glue' directly mediating T cell–DC binding. Using primary human cells, we observed...

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Detalhes bibliográficos
Main Authors: Bollyky, Paul L, Evanko, Stephen P, Wu, Rebecca P, Potter-Perigo, Susan, Long, S Alice, Kinsella, Brian, Reijonen, Helena, Guebtner, Kelly, Teng, Brandon, Chan, Christina K, Braun, Kathy R, Gebe, John A, Nepom, Gerald T, Wight, Thomas N
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3027489/
https://ncbi.nlm.nih.gov/pubmed/20228832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2010.9
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