Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation

Rearrangements of the MLL (ALL1) gene are very common in acute infant and therapy-associated leukemias. The rearrangements underlie the generation of MLL fusion proteins acting as potent oncogenes. Several most consistently up-regulated targets of MLL fusions, MEIS1, HOXA7, HOXA9, and HOXA10 are fun...

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Hlavní autoři: Orlovsky, Kira, Kalinkovich, Alexander, Rozovskaia, Tanya, Shezen, Elias, Itkin, Tomer, Alder, Hansjuerg, Ozer, Hatice Gulcin, Carramusa, Letizia, Avigdor, Abraham, Volinia, Stefano, Buchberg, Arthur, Mazo, Alex, Kollet, Orit, Largman, Corey, Croce, Carlo M., Nakamura, Tatsuya, Lapidot, Tsvee, Canaani, Eli
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2011
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093458/
https://ncbi.nlm.nih.gov/pubmed/21518888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1103154108
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