ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia

Rearrangements of the ALL-1/MLL1 gene underlie the majority of infant acute leukaemias, as well as of therapy-related leukaemias developing in cancer patients treated with inhibitors of topoisomerase II, such as VP16 and doxorubicin. The rearrangements fuse ALL-1 to any of >50 partner genes or to...

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Hlavní autoři: Canaani, E, Nakamura, T, Rozovskaia, T, Smith, S T, Mori, T, Croce, C M, Mazo, A
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2004
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2410188/
https://ncbi.nlm.nih.gov/pubmed/14970849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601639
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