PRL-3, a Metastasis Associated Tyrosine Phosphatase, Is Involved in FLT3-ITD Signaling and Implicated in Anti-AML Therapy

Combination with other small molecule drugs represents a promising strategy to improve therapeutic efficacy of FLT3 inhibitors in the clinic. We demonstrated that combining ABT-869, a FLT3 inhibitor, with SAHA, a HDAC inhibitor, led to synergistic killing of the AML cells with FLT3 mutations and sup...

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Autori principali: Zhou, Jianbiao, Bi, Chonglei, Chng, Wee-Joo, Cheong, Lip-Lee, Liu, Shaw-Cheng, Mahara, Sylvia, Tay, Kian-Ghee, Zeng, Qi, Li, Jie, Guo, Ke, Tan, Cheng Peow Bobby, Yu, Hanry, Albert, Daniel H., Chen, Chien-Shing
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093398/
https://ncbi.nlm.nih.gov/pubmed/21589872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019798
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