Contribution of Cytochrome P450 and ABCB1 Genetic Variability on Methadone Pharmacokinetics, Dose Requirements, and Response

Although the efficacy of methadone maintenance treatment (MMT) in opioid dependence disorder has been well established, the influence of methadone pharmacokinetics in dose requirement and clinical outcome remains controversial. The aim of this study is to analyze methadone dosage in responder and no...

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Detalhes bibliográficos
Main Authors: Fonseca, Francina, de la Torre, Rafael, Díaz, Laura, Pastor, Antonio, Cuyàs, Elisabet, Pizarro, Nieves, Khymenets, Olha, Farré, Magí, Torrens, Marta
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093392/
https://ncbi.nlm.nih.gov/pubmed/21589866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019527
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