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Within- and between- subject variability in methadone pharmacokinetics and pharmacodynamics in methadone maintenance subjects

AIMS: To investigate within- and between-subject variability of the pharmacodynamics and pharmacokinetics of (R)- and (S)-methadone in methadone maintenance subjects at steady-state. METHODS: Six non-holder subjects were studied on three occasions at 7–16 day intervals; doses (20–170 mg/day) remaine...

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Detalhes bibliográficos
Main Authors: Hanna, Julia, Foster, David JR, Salter, Amy, Somogyi, Andrew A, White, Jason M, Bochner, Felix
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884832/
https://ncbi.nlm.nih.gov/pubmed/16187972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2005.02464.x
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