Altered mRNA Editing and Expression of Ionotropic Glutamate Receptors after Kainic Acid Exposure in Cyclooxygenase-2 Deficient Mice

Kainic acid (KA) binds to the AMPA/KA receptors and induces seizures that result in inflammation, oxidative damage and neuronal death. We previously showed that cyclooxygenase-2 deficient (COX-2(−/−)) mice are more vulnerable to KA-induced excitotoxicity. Here, we investigated whether the increased...

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Hauptverfasser: Caracciolo, Luca, Barbon, Alessandro, Palumbo, Sara, Mora, Cristina, Toscano, Christopher D., Bosetti, Francesca, Barlati, Sergio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093380/
https://ncbi.nlm.nih.gov/pubmed/21589914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019398
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