Zinc Binding to the Tyr402 and His402 Allotypes of Complement Factor H: Possible Implications for Age-Related Macular Degeneration

The Tyr402His polymorphism of complement factor H (FH) with 20 short complement regulator (SCR) domains is associated with age-related macular degeneration (AMD). How FH contributes to disease pathology is not clear. Both FH and high concentrations of zinc are found in drusen deposits, the key featu...

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Detalhes bibliográficos
Main Authors: Nan, Ruodan, Farabella, Irene, Schumacher, Felix F., Miller, Ami, Gor, Jayesh, Martin, Andrew C.R., Jones, David T., Lengyel, Imre, Perkins, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092982/
https://ncbi.nlm.nih.gov/pubmed/21396937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.03.006
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