Zinc-induced Self-association of Complement C3b and Factor H: IMPLICATIONS FOR INFLAMMATION AND AGE-RELATED MACULAR DEGENERATION

The sub-retinal pigment epithelial deposits that are a hallmark of age-related macular degeneration contain both C3b and millimolar levels of zinc. C3 is the central protein of complement, whereas C3u is formed by the spontaneous hydrolysis of the thioester bridge in C3. During activation, C3 is cle...

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Main Authors: Nan, Ruodan, Tetchner, Stuart, Rodriguez, Elizabeth, Pao, Po-Jung, Gor, Jayesh, Lengyel, Imre, Perkins, Stephen J.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2013
主題:
Immunology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696691/
https://ncbi.nlm.nih.gov/pubmed/23661701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.476143
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