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Ectopic expression of Cux1 is associated with reduced p27 expression and increased apoptosis during late stage cyst progression upon inactivation of Pkd1 in collecting ducts

Polycystic kidney diseases (PKD) are inherited disorders characterized by fluid-filled cysts primarily in the kidneys. We previously reported differences between the expression of Cux1, p21 and p27 in the cpk and Pkd1 null mouse models of PKD. Embryonic lethality of Pkd1 null mice limits its study t...

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Detalhes bibliográficos
Main Authors: Paul, Binu M., Vassmer, Dianne, Taylor, Aaron, Magenheimer, Lynn, Carlton, Carol G., Piontek, Klaus B., Germino, Gregory G., Vanden Heuvel, Gregory B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092830/
https://ncbi.nlm.nih.gov/pubmed/21465620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.22625
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